Endocrine Abstracts

Metabolic fluxes in the liver demonstrate circadian rhythms. The hepatic circadian clock is a cell- autonomous protein network that governs the switch between the fasted and fed states via a series of transcriptional-translational feedback loops (TTLs). Diet is a powerful zeitgeber which can reprogramme the liver clock to follow eating schedule rather than the geophysical day-night cycle. Diet- induced circadian disruption has been implicated in the pathogenesis of common meta...